Ethical decision-making has long been recognized as critical for Industrial-Organizational psychologists in the variety of roles they fill in education, research, and practice. Decisions with ethical implications are not always readily apparent and often require consideration of competing concerns. The American Psychological Association (APA) Ethical Principles of Psychologists and Code of Conduct are the principles and standards to which all SIOP members are held accountable and serve to aid in decision-making. To this end, the primary focus of this article is the development and presentation of an integrative ethical decision-making framework rooted in and inspired by empirical, philosophical, and practical considerations of professional ethics in APA. The purpose of this framework is to provide a generalizable model that can be used to identify, evaluate, resolve, and engage in discourse about topics involving ethical issues. To demonstrate the efficacy of this general framework to contexts germane to I-O psychologists, we subsequently present and apply this framework to five scenarios, each involving an ethical situation relevant to academia, practice, or graduate education in I-O psychology. We hope to stimulate the refinement of ethical decisionmaking, illustrate its application in our profession, and advance conversations about ethical practices.